Rare increased heart rate, decreased blood pressure. Very rare (shock-like) vascular collapse. In some cases: lengthening of the tren hexahydrobenzylcarbonate interval.The action on the muscles, tendons and bones. Rare: defeat tendons (including tendonitis), joint and muscle pain
Very rare: tendon rupture (eg Achilles tendon); this side effect may occur within 48 hours after the start of treatment and may be bilateral in nature (see “Cautions.”); muscle weakness, which is of particular importance for patients suffering from myasthenia gravis.
In some cases: muscle damage (rhabdomyolysis).Effects on the liver and kidneysOften: increased activity of liver enzymes (eg, alanine aminotransferase and aspartate aminotransferase).
Rare: increased bilirubin and serum creatinine (sign of limitation of liver or kidney function).
Very rare: hepatic reactions (eg, inflammation of the liver); deterioration of renal function until the acute renal failure, for example, due to allergic reactions (interstitial nephritis).Haematic. Sometimes: increase in the number of eosinophils, a decrease in the number of white blood cells
Rare: neutropenia; thrombocytopenia, which may be accompanied by increased bleeding.
Very rare: agranulocytosis and the development of severe infections (persistent or recurrent fever, sore throat and a persistent deterioration of health).
In some cases: haemolytic anemia; pancytopenia.Other side effectsSometimes:. General weakness (asthenia)
Very rarely. Fever, allergic pneumonitis
Any antibiotic therapy can cause changes in the microflora (bacteria and fungi), which is normally present in humans. For this reason, it may happen enhanced reproduction of bacteria and fungi that are resistant to antibiotics are used (secondary infection tren hexahydrobenzylcarbonate and superinfection), which in rare cases may require additional treatment.
The most important expected symptoms (signs) of erroneous overdosing tavanic occur at the level of the central nervous system (confusion, dizziness, impairment of consciousness and seizures seizures by type epipripadkov). In addition, it can be marked gastrointestinal symptoms (eg, nausea) and erosive lesions of the mucous membranes.
The clinical and pharmacological studies conducted by the supra-therapeutic doses of levofloxacin was shown lengthening the interval.
Treatment should be focused on presenting symptoms. Levofloxacin is not displayed by dialysis (hemodialysis, peritoneal dialysis and continuous peritoneal dialysis). Specific antidote (counteracting agent) does not exist. Error receiving one extra of the drug will have no harmful effects.
Interaction with other drugs
There are reports of pronounced lowering the threshold of convulsive readiness, while the use of quinolones and substances that can, in turn, lower the cerebral seizure threshold. Equally, it also relates to the simultaneous use of quinolones and theophylline, fenbufena tren hexahydrobenzylcarbonate or similar to it nonsteroidal antiinflammatory drugs (for the treatment of rheumatic diseases).
The drug tavanic expression weakened, while the use of sucralfate (means to protect the gastric mucosa). The same thing happens with the simultaneous use of magnesium-aluminum containing antacids or (drugs for the treatment of heartburn and gastralgia), as well as salts of iron (for the treatment of anemia). Tavanic should take no less than 2 hours before or 2 hours after the administration of these agents.With calcium carbonate interaction have been identified. Receiving corticosteroids increase the risk of tendon rupture.
With the simultaneous use of vitamin K antagonists should be monitored for blood coagulation system.
Excretion (renal clearance) of levofloxacin slightly slowed down by the action of cimetidine and probenicid. It should be noted that this interaction is almost does not have any clinical significance. However, while the use of drugs such as cimetidine and probenicid blocking certain way of deducing (tubular secretion), treatment with levofloxacin should be performed with caution. This applies primarily to patients with reduced renal function.
Levofloxacin slightly increases the tren hexahydrobenzylcarbonate of cyclosporin.
Receiving corticosteroids increase the risk of tendon rupture.