Relationship to plasma proteins is 95%. Excretion of plasma dwuhfazno corresponding  hours. Clemastine subject to significant metabolism in the liver. Metabolites in the ground (45 – 65%) excreted through the kidneys in the urine; unmodified active substance found in urine in trace amounts only. During lactation a small amount of clemastine can penetrate into breast milk.

Indications
– prevention or treatment of allergic reactions and pseudoallergic (including the introduction of contrast agents, blood transfusion, diagnostic application of histamine)
– angioedema, anaphylactic or anaphylactoid shock (as an adjunct).

Contraindications:
Hypersensitivity, pregnancy, lactation, taking monoamine oxidase inhibitors parabolan dosage, lower respiratory diseases (including asthma), fructose intolerance, children up to 1 year.

Intra-arterial injection of the drug is not permitted!

The caution
in patients with ulcer stenosing gastric piloroduodenalnoy obstruction, with obstruction of the bladder neck and prostatic hypertrophy, accompanied by urinary retention with increased intraocular pressure, hyperthyroidism, diseases of the cardiovascular system, including hypertension.

Pregnancy and lactation
Use of the drug during pregnancy and lactation is contraindicated.

Dosage and administration
intravenously or intramuscularly. Adults: 2 mg (2 ml), that is, the contents of 1 mg, 2 times a day (morning and evening). For prophylaxis intravenously administered drug slowly (within 2-3 min or more) at a dose of 2 mg possible immediately before the occurrence of anaphylactic reactions or reactions in response to the use of histamine. The solution preparation can be further diluted with isotonic sodium chloride solution or 5% glucose solution in the ratio 1: 5. Babies: 0,025 mg / kg per day intramuscularly, dividing by 2 injection.

From the nervous system:
Common: fatigue, somnolence, sedation, weakness, fatigue, lethargy, incoordination;
Uncommon: dizziness
Rare: headache, tremor, stimulating effect.

From the gastrointestinal tract:
Rare: dyspepsia, nausea, vomiting, gastralgia, dry mouth
Very rare: constipation.

From the senses:
Rare: violation of clarity of vision, diplopia, acute labyrinthitis, tinnitus.

On the part of the kidney and urinary tract:
Very rare: palpitations, or difficulty urinating.

Respiratory system:
rare: thickening of bronchial parabolan dosage secretions and difficulty sputum discharge, feeling of pressure in the chest, respiratory failure, nasal congestion.

Cardio-vascular system:
Rare:. Decrease in blood pressure (often in elderly patients), extrasystoles
Very rare: tachycardia.

From the blood and blood-forming organs:
Occasionally: hemolytic anemia, thrombocytopenia, agranulocytosis.

Skin and subcutaneous tissue:
Rare: skin rash.

Immune system:
Uncommon: photosensitivity, shortness of breath,
rarely: anaphylactic shock.

If any of these instructions side effects are compounded, or if you notice any other side effects not mentioned in the instructions, inform your doctor.

Overdose Symptoms. Overdose antihistamines can lead to both depressing and a stimulating effect on the central nervous system, most often seen in children. Also, the phenomenon may develop anticholinergic action: dry mouth, fixed dilated pupils, flushing to the upper half of the body, tachycardia, disorders of the gastrointestinal tract (nausea, epigastric pain, vomiting). Treatment. Symptomatic therapy.

Interaction with other drugs
Parabolan dosage increases the effects of drugs, central nervous system depressants (hypnotics, sedatives, anxiolytics), m-cholinergic antagonists, as well as alcohol. Incompatible with the simultaneous intake of MAO inhibitors.

Cautions
Clemastine has a slight sedation (from mild to moderate in intensity),  are advised to refrain from driving vehicles, using machinery, as well as other activities that require high concentration and speed of psychomotor reactions.