In the fall of neutrophil count trenbolone side effects was observed more than a week, or the development of febrile neutropenia, or the development of severe skin reactions or severe peripheral neuropathy during therapy with docetaxel, the dose of the drug for the following introductions should be reduced . If such complications occur when applying and docetaxel 60 mg / m 2 , the treatment should be discontinued.
In the combination therapy of breast cancer.
Patients with resectable form of breast cancer receiving adjuvant therapy, during the development of febrile neutropenia should receive in all subsequent cycles. When you save a febrile netropenii need to reduce the dose of , If is not used to Taxotere dose should be reduced . Stomatitis in patients with grade 3 or 4 necessary to decrease .
With the combination of Taxotere with capecitabine:
The first appearance of grade 2 toxicity, which persists until the time of the next cycle of treatment Taxotere / capecitabine, the next treatment cycle may be postponed to reduce toxicity to 0-1 degrees, while during the next cycle of treatment is introduced 100% initial dose of Taxotere.
Patients with recurrent developmental toxicity grade 2 toxicity, or development of the first 3 degrees at any time a treatment cycle, the treatment is delayed to reduce the degree of toxicity to 0-1, then Taxotere treatment is resumed 2 .
If any further manifestations of toxicity, or the appearance of any kind of grade 4 toxicity Taxotere administration should be discontinued.
With regard to the capecitabine dose adjustment when combined with trenbolone side effects, see the instructions for use of capecitabine.
In the combination therapy
For patients who initially receive trenbolone side effects in combination with cisplatin or carboplatin in which the platelet count in the previous cycle of treatment was reduced (with cisplatin) and up to <75,000 / ul (carboplatin), or in patients who have developed a febrile neutropenia, or in patients with severe manifestations of hematological toxicity dose of Taxotere in the next cycle to be reduced to 65 mg / m 2 . For recommendations on dose adjustment for the use of cisplatin, see the instructions of cisplatin.
With the combination of plus cisplatin and 5-fluorouracil
In developing febrile neutropenia or accession infection despite receiving , dose should be . Upon subsequent development episodes neutropenia complicated recommended to reduce . With the development of thrombocytopenia grade 4 dose of it is recommended to reduce .Subsequent cycles of docetaxel with possible when the number of neutrophilsmicroliter.When you save toxicity, treatment should be discontinued.